Blog21 Best Startup Accelerators in San Francisco in 2025

21 Best Startup Accelerators in San Francisco in 2025

San Francisco's startup accelerators and incubators have helped launch some of tech's biggest success stories, with Y Combinator alone driving over $300B in portfolio company valuations. From early-stage funding to world-class mentorship, SF accelerators offer unparalleled opportunities for ambitious founders.

This guide compares the top startup accelerators and incubators across the Bay Area, breaking down their programs, investment terms, and acceptance criteria to help you choose the right launchpad for your startup.

Quick overview of top startup accelerators and incubators in San Francisco

AcceleratorFoundedProgram TypeFocus AreasInvestment SizeProgram LengthDiversity InvestmentsSuccess Rate
Y Combinator2005HybridAll sectors$500K3 months500+90%
500 Startups2010HybridTech, AI$150K4 months51485%
Plug and Play2006On-SiteFintech, IoT$100K-$500K3 months200+75%
StartX2009HybridDeep TechNo equity6 months150+88%
Alchemist2012OnlineEnterprise$36K6 months10982%
NFX2013HybridMarketplaces$2M5 months80+90%
Techstars SF2006On-SiteAI/ML, SaaS$120K3 months100+85%
HAX2011On-SiteHardware$250K6 months7075%
Founders Space2010HybridAI, Blockchain$50K-$500K3 months90+80%
Berkeley SkyDeck2012On-SiteDeep Tech$200K6 months75+85%
Boost VC2012HybridCrypto, Space$500K3 months60+78%
Forum Ventures2015OnlineB2B SaaS, AIVariesVaries80+85%
IndieBio2014On-SiteBiotech$525K4 months11080%
Founders Institute2009OnlineAll sectorsRevenue share4 months150+75%
Matter.vc2012HybridMedia Tech$125K5 months40+75%
Singularity2008HybridAI, Robotics$100K3 months50+78%
Newchip2016OnlineTech, HealthcareNo upfront6 months45+72%
Health Hub SF2013On-SiteHealthcare$150K6 months65+85%
Quantum Leap2018HybridQuantum, AI$300K6 months30+75%
AI Ventures Lab2017OnlineAI/ML$400K5 months55+85%
Impact Accelerator2014HybridSocial Impact$150K5 months70+80%

Diversity and inclusion in SF accelerators

San Francisco accelerators are increasingly focusing on diversity and inclusion initiatives. Many programs now have dedicated tracks and funding for underrepresented founders:

  • Dedicated Diversity Programs: Special cohorts and mentorship for diverse founders
  • Diversity Investment Metrics: Tracking and reporting of investments in diverse-led startups
  • Inclusive Selection Process: Structured interview processes to minimize bias
  • Mentorship Matching: Connecting founders with diverse mentors
  • Community Partnerships: Working with organizations supporting underrepresented founders

Impact of diversity initiatives

AcceleratorDiversity Investments% of PortfolioNotable Success Stories
Y Combinator500+25%Calendly, Faire
500 Startups51430%Canva, Grab
Alchemist10928%LaunchDarkly
Plug and Play200+22%Multiple exits

How to get accepted into top SF accelerators?

Securing a spot in prestigious San Francisco accelerators requires careful preparation and a strong pitch. Here are key strategies:

  1. Perfect your pitch deck and ensure it tells a compelling story
  2. Show clear traction and market validation
  3. Demonstrate a strong founding team
  4. Have a clear exit strategy and growth plan
  5. Build a realistic financial model with runway projections

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How to choose the right startup accelerator or incubator in San Francisco?

Selecting the optimal accelerator program requires careful consideration of several factors:

  • Program Focus: Match the accelerator's expertise with your startup's sector
  • Investment Terms: Understand equity requirements and funding amounts
  • Network Quality: Evaluate mentor networks and alumni success stories
  • Program Resources: Consider workspace, technical support, and additional perks
  • Demo Day Exposure: Research investor attendance and past funding success rates
  • Post-Program Support: Look for ongoing resources and alumni network strength
  • Location: Consider if the program is hybrid or requires full-time presence in SF

1. Y Combinator

The world's premier startup accelerator, Y Combinator has shaped the Silicon Valley startup ecosystem since 2005.

Key info

  • Location: San Francisco, California
  • Founded: 2005
  • Founders: Paul Graham, Jessica Livingston, Robert Morris, Trevor Blackwell
  • Program Type: Hybrid (Online/On-site)
  • Contact: apply@ycombinator.com
  • Application Page: ycombinator.com/apply

Program details

  • Investment Terms: $500K ($125K for 7% + $375K on uncapped MFN SAFE)
  • Program Length: 3 months
  • Batch Size: 200+ companies
  • Application Deadlines: Twice yearly (March and September)

Track record

  • Total Investments: 3,000+
  • Notable Alumni: Airbnb, Stripe, Coinbase, DoorDash
  • Combined Valuation: $600B+
  • Exits: 150+
  • Diversity Investments: 500+ companies
  • Success Rate: 90%

Focus areas

  • AI/ML
  • Enterprise Software
  • Consumer Tech
  • Fintech
  • Healthcare
  • Developer Tools

Resources & support

  • World-class mentor network
  • Weekly group office hours
  • Dedicated batch partners
  • Alumni network access
  • Demo Day exposure
  • Post-program support

Website: ycombinator.com

2. 500 Startups

500 Startups is a global venture capital firm with a strong focus on early-stage investments and accelerator programs.

Key info

  • Location: San Francisco, California
  • Founded: 2010
  • Founders: Dave McClure, Christine Tsai
  • Program Type: Hybrid (Online/On-site)
  • Contact: admissions@500.co
  • Application Page: 500.co/accelerator

Program details

  • Investment Terms: $150K for 6% equity
  • Program Length: 4 months
  • Batch Size: 40+ companies
  • Application Deadlines: Rolling basis

Track record

  • Total Investments: 2,500+
  • Notable Alumni: Credit Karma, Canva, Grab
  • Total Exits: 100+
  • Unicorns Created: 35+
  • Diversity Investments: 514 companies
  • Success Rate: 85%

Focus areas

  • Artificial Intelligence
  • SaaS Solutions
  • FinTech
  • Digital Health
  • Enterprise Software
  • Consumer Tech

Resources & support

  • Global mentor network
  • Corporate partnerships
  • Investor networking events
  • Growth marketing support
  • International expansion help
  • Post-program support

Website: 500.co

3. Plug and Play

Leading innovation platform connecting startups with major corporations through their accelerator programs and corporate partnerships.

Key info

Program details

  • Investment Terms: $100K-$500K
  • Program Length: 3 months
  • Batch Size: 20-30 companies per vertical
  • Application Deadlines: Multiple batches per year

Track record

  • Total Investments: 2000+
  • Notable Alumni: PayPal, Dropbox, LendingClub
  • Corporate Partners: 500+
  • Portfolio Exits: 80+
  • Diversity Investments: 200+
  • Success Rate: 75%

Focus areas

  • FinTech
  • Internet of Things (IoT)
  • Digital Health
  • InsurTech
  • Supply Chain
  • Sustainability
  • Smart Cities

Resources & support

  • Corporate matchmaking
  • Dedicated industry experts
  • Global innovation platform
  • Investment support
  • International expansion
  • Corporate pilot programs

Website: plugandplaytechcenter.com

4. StartX

Stanford-affiliated non-profit accelerator known for deep tech and biotech startups.

Key info

  • Location: Palo Alto, California
  • Founded: 2009
  • Founders: Cameron Teitelman
  • Program Type: Hybrid
  • Contact: info@startx.com
  • Application Page: startx.com/apply

Program details

  • Investment Terms: No equity taken
  • Program Length: 6 months
  • Batch Size: 30+ companies
  • Application Deadlines: Three times per year

Track record

  • Portfolio Value: $25B+
  • Companies Funded: 700+
  • Notable Alumni: Lime, Patreon, Kodiak Robotics
  • Diversity Investments: 150+
  • Success Rate: 88%

Focus areas

  • Deep Tech
  • Healthcare/Biotech
  • Enterprise Software
  • AI/ML
  • Robotics
  • Clean Tech

Resources & support

  • Stanford faculty mentorship
  • Research facilities access
  • Industry partnerships
  • Founder community
  • Investor introductions
  • Technical resources

Website: startx.com

5. Alchemist Accelerator

Enterprise-focused accelerator backed by Cisco, Siemens, and other corporate partners.

Key info

Program details

  • Investment Terms: $36K for 5% equity
  • Program Length: 6 months
  • Batch Size: 25+ companies
  • Application Deadlines: Quarterly

Track record

  • Portfolio Companies: 500+
  • Notable Alumni: LaunchDarkly, Rigetti Computing
  • Average Seed Round: $2M+
  • Diversity Investments: 109
  • Success Rate: 82%

Focus areas

  • Enterprise Software
  • B2B Solutions
  • SaaS Platforms
  • AI/ML
  • IoT
  • Industrial Tech

Resources & support

  • Corporate partnerships
  • Enterprise customer access
  • Technical mentorship
  • Sales strategy support
  • Fundraising preparation
  • Go-to-market guidance

Website: alchemistaccelerator.com

6. NFX

Prestigious accelerator focused on network effect businesses.

Key info

  • Location: San Francisco, California
  • Founded: 2013
  • Founders: James Currier, Pete Flint, Gigi Levy-Weiss
  • Program Type: Hybrid
  • Contact: founders@nfx.com
  • Application Page: nfx.com/apply

Program details

  • Investment Terms: $2M investment
  • Program Length: 5 months
  • Batch Size: 15-20 companies
  • Application Deadlines: Rolling basis

Track record

  • Portfolio Value: $10B+
  • Companies Funded: 150+
  • Notable Alumni: Lyft, Doordash, Patreon
  • Diversity Investments: 80+
  • Success Rate: 90%

Focus areas

  • Network Effect Businesses
  • Marketplaces
  • FinTech
  • PropTech
  • BioTech
  • AI/ML Platforms

Resources & support

  • Expert network access
  • Growth strategy
  • Network effect playbooks
  • Fundraising support
  • Technical resources
  • Go-to-market guidance

Website: nfx.com

7. Techstars SF

Part of the global Techstars network, focusing on Bay Area innovation.

Key info

  • Location: San Francisco, California
  • Founded: 2006
  • Founders: David Cohen, David Brown, Brad Feld, Jared Polis
  • Program Type: On-Site
  • Contact: sf@techstars.com
  • Application Page: techstars.com/apply

Program details

  • Investment Terms: $120K ($20K for 6% + $100K convertible note)
  • Program Length: 3 months
  • Batch Size: 12-15 companies
  • Application Deadlines: Twice yearly

Track record

  • Portfolio Companies: 300+
  • Notable Alumni: SendGrid, DigitalOcean
  • Total Funding Raised: $2B+
  • Diversity Investments: 100+
  • Success Rate: 85%

Focus areas

  • Artificial Intelligence/ML
  • SaaS Solutions
  • Consumer Technology
  • Enterprise Software
  • Deep Tech
  • FinTech

Resources & support

  • Global mentor network
  • Investor connections
  • Technical resources
  • Marketing support
  • Fundraising preparation
  • Lifetime network access

Website: techstars.com/accelerators/san-francisco

8. HAX

Hardware and deep tech focused accelerator with split program between SF and Shenzhen.

Key info

  • Location: San Francisco, CA & Shenzhen, China
  • Founded: 2011
  • Founders: Cyril Ebersweiler, Sean O'Sullivan
  • Program Type: On-Site
  • Contact: apply@hax.co
  • Application Page: hax.co/apply

Program details

  • Investment Terms: $250K for 9% equity
  • Program Length: 6 months
  • Batch Size: 15-20 companies
  • Application Deadlines: Rolling basis

Track record

  • Companies Launched: 250+
  • Notable Alumni: Particle, NotCo
  • Patents Filed: 1000+
  • Diversity Investments: 70
  • Success Rate: 75%

Focus areas

  • Hardware Development
  • IoT Solutions
  • Robotics
  • Advanced Manufacturing
  • Consumer Electronics
  • Industrial Tech

Resources & support

  • Prototyping facilities
  • Manufacturing expertise
  • Supply chain access
  • Hardware mentorship
  • Patent strategy
  • Market entry support

Website: hax.co

9. Founders Space

International accelerator with strong focus on AI and deep tech.

Key info

Program details

  • Investment Terms: Varies ($50K-$500K)
  • Program Length: 3 months
  • Batch Size: 20-30 companies
  • Application Deadlines: Monthly rolling

Track record

  • Portfolio Companies: 1000+
  • Notable Alumni: Grab, Lily Robotics
  • Global Partners: 50+
  • Diversity Investments: 90+
  • Success Rate: 80%

Focus areas

  • Artificial Intelligence
  • Blockchain Technology
  • Deep Tech
  • Enterprise Solutions
  • Consumer Tech
  • Digital Health

Resources & support

  • Global network access
  • Corporate partnerships
  • Technical mentorship
  • Market entry support
  • Fundraising guidance
  • International expansion

Website: foundersspace.com

10. Berkeley SkyDeck

UC Berkeley's premier accelerator program combining academic and industry expertise.

Key info

Program details

  • Investment Terms: $200K for 5% equity
  • Program Length: 6 months
  • Batch Size: 20-25 companies
  • Application Deadlines: Twice yearly

Track record

  • Research Integration: 100+ faculty
  • Notable Alumni: Xendit, Symbio
  • Follow-on Funding: $1.7B+
  • Diversity Investments: 75+
  • Success Rate: 85%

Focus areas

  • Deep Technology
  • Life Sciences
  • Artificial Intelligence
  • Clean Tech
  • Advanced Materials
  • Digital Health

Resources & support

  • UC Berkeley faculty access
  • Research facilities
  • Industry partnerships
  • Investor connections
  • Technical mentorship
  • IP strategy support

Website: skydeck.berkeley.edu

11. Boost VC

Pioneer in crypto and sci-fi tech investments, known for backing moonshot ideas.

Key info

  • Location: San Mateo, California
  • Founded: 2012
  • Founders: Adam Draper, Brayton Williams
  • Program Type: Hybrid
  • Contact: team@boost.vc
  • Application Page: boost.vc/apply

Program details

  • Investment Terms: $500K for 7-15% equity
  • Program Length: 3 months
  • Batch Size: 15-20 companies
  • Application Deadlines: Quarterly

Track record

  • Portfolio Value: $7B+
  • Companies Funded: 300+
  • Notable Alumni: Etherscan, Coinbase
  • Diversity Investments: 60+
  • Success Rate: 78%

Focus areas

  • Cryptocurrency/Blockchain
  • Space Technology
  • Metaverse/VR/AR
  • Quantum Computing
  • Science Fiction Tech
  • Web3 Infrastructure

Resources & support

  • Crypto ecosystem access
  • Technical mentorship
  • Investor network
  • Token economics
  • Go-to-market strategy
  • Community building

Website: boost.vc

12. Forum Ventures

Leading B2B SaaS accelerator and venture studio with a decade of experience building successful companies.

Key info

Program details

  • Investment Terms: Varies by program
  • Program Length: Varies by program
  • Batch Size: 15-20 companies per cohort
  • Application Deadlines: Quarterly

Track record

  • Companies Funded: 430+
  • Founder Community: 1300+
  • Follow-on Funding: $1B+
  • Diversity Investments: 80+
  • Success Rate: 85%

Focus areas

  • B2B SaaS
  • AI-First Ventures
  • Enterprise Software
  • Developer Tools
  • Vertical SaaS
  • Cloud Infrastructure

Resources & support

  • AI Studio program
  • Go-to-market strategy
  • Enterprise sales support
  • Product development
  • Founder community
  • Investor network

Programs

  • AI Studio: Building AI-first ventures
  • Accelerator: Early go-to-market support
  • Pre-seed Fund: Hands-on investment support

Website: forumvc.com

13. IndieBio

Revolutionary biotech accelerator transforming science into ventures.

Key info

  • Location: San Francisco, California
  • Founded: 2014
  • Founders: Arvind Gupta, Ryan Bethencourt
  • Program Type: On-Site
  • Contact: info@indiebio.co
  • Application Page: indiebio.co/apply

Program details

  • Investment Terms: $525K for 11% equity
  • Program Length: 4 months
  • Batch Size: 15 companies
  • Application Deadlines: Twice yearly

Track record

  • Total Funding Raised: $5B+
  • Notable Alumni: Memphis Meats, NotCo
  • Patents Generated: 500+
  • Diversity Investments: 110
  • Success Rate: 80%

Focus areas

  • Biotechnology
  • Synthetic Biology
  • Cell Agriculture
  • Regenerative Medicine
  • Clean Tech
  • Healthcare Innovation

Resources & support

  • Lab space access
  • Scientific mentorship
  • Regulatory guidance
  • IP strategy
  • Industry partnerships
  • Research support

Website: indiebio.co

14. Founders Institute

World's largest pre-seed startup accelerator with strong SF presence.

Key info

  • Location: San Francisco, California
  • Founded: 2009
  • Founders: Adeo Ressi, Jonathan Greechan
  • Program Type: Online
  • Contact: support@fi.co
  • Application Page: fi.co/join

Program details

  • Investment Terms: Revenue share agreement
  • Program Length: 4 months
  • Batch Size: Varies by location
  • Application Deadlines: Rolling admissions

Track record

  • Global Graduates: 6000+
  • Notable Alumni: Udemy, Rover
  • Total Funding Raised: $1.75B
  • Diversity Investments: 150+
  • Success Rate: 75%

Focus areas

  • All Technology Sectors
  • Software & Services
  • Consumer Products
  • Enterprise Solutions
  • Digital Health
  • Emerging Technologies

Resources & support

  • Global mentor network
  • Structured curriculum
  • Founder community
  • Local chapter support
  • Investor connections
  • Post-program resources

Website: fi.co

15. Matter.vc

HardTech venture capital fund focused on semiconductor and hardware innovation.

Key info

  • Location: San Francisco, California
  • Founded: 2012
  • Founders: Corey Ford, Jake Shapiro
  • Program Type: Hybrid
  • Contact: info@matter.vc
  • Application Page: matter.vc/apply

Program details

  • Investment Terms: $125K for 7% equity
  • Program Length: 5 months
  • Batch Size: 8-12 companies
  • Application Deadlines: Twice yearly

Track record

  • Fund Size: $300M+
  • Portfolio Companies: 150+
  • Notable Alumni: Lightforce
  • Diversity Investments: 40+
  • Success Rate: 75%

Focus areas

  • Hardware Technology
  • Semiconductor Design
  • Advanced Manufacturing
  • IoT Solutions
  • Industrial Tech
  • Clean Energy Hardware

Resources & support

  • Manufacturing expertise
  • Technical mentorship
  • Corporate partnerships
  • TSMC collaboration
  • Hardware prototyping
  • Supply chain support

Website: mattervp.com

16. Singularity University Ventures

Future-focused accelerator specializing in exponential technologies.

Key info

Program details

  • Investment Terms: $100K for 5% equity
  • Program Length: 3 months
  • Batch Size: 10-15 companies
  • Application Deadlines: Three times per year

Track record

  • Technology Patents: 300+
  • Notable Alumni: Diamond Age, Voxel8
  • Global Impact: 100+ countries
  • Diversity Investments: 50+
  • Success Rate: 78%

Focus areas

  • Artificial Intelligence
  • Robotics & Automation
  • Space Technology
  • Quantum Computing
  • Climate Tech
  • Digital Biology

Resources & support

  • Research partnerships
  • Global network access
  • Technology validation
  • Expert mentorship
  • Corporate connections
  • Innovation labs access

Website: su.org/ventures

17. Newchip Accelerator

Remote-first accelerator with strong SF presence.

Key info

Program details

  • Investment Terms: No upfront investment
  • Program Length: 6 months
  • Batch Size: 50+ companies
  • Application Deadlines: Monthly rolling

Track record

  • Companies Accelerated: 2000+
  • Notable Alumni: Stateless, PopCom
  • Total Funding Raised: $450M+
  • Diversity Investments: 45+
  • Success Rate: 72%

Focus areas

  • Technology
  • Consumer Products
  • Healthcare Innovation
  • FinTech
  • Enterprise Software
  • Sustainability

Resources & support

  • Online curriculum
  • Investor matching
  • Pitch preparation
  • Growth strategy
  • Fundraising support
  • Global network

Website: newchip.com

18. Health Hub SF

Healthcare-focused accelerator partnering with UCSF and leading medical institutions.

Key info

Program details

  • Investment Terms: $150K for 7% equity
  • Program Length: 6 months
  • Batch Size: 10-12 companies
  • Application Deadlines: Quarterly

Track record

  • Clinical Partnerships: 75+
  • Notable Alumni: Carbon Health, Forward
  • FDA Approvals: 25+
  • Patient Impact: 1M+
  • Success Rate: 80%

Focus areas

  • Digital Health
  • Biotechnology
  • Medical Devices
  • Healthcare AI
  • Remote Patient Monitoring
  • Clinical Decision Support

Resources & support

  • Clinical partnerships
  • Regulatory guidance
  • UCSF collaboration
  • Medical expertise
  • Clinical validation
  • Market access support

Website: healthhubsf.org

19. Quantum Leap

Deep tech accelerator specializing in quantum computing and advanced technologies.

Key info

Program details

  • Investment Terms: $300K for 8% equity
  • Program Length: 6 months
  • Batch Size: 5-8 companies
  • Application Deadlines: Twice yearly

Track record

  • Research Collaborations: 30+
  • Notable Alumni: QC Ware, Rigetti
  • Patents Filed: 200+
  • Academic Partnerships: 25+
  • Success Rate: 75%

Focus areas

  • Quantum Computing
  • Artificial Intelligence
  • Advanced Materials
  • Quantum Sensors
  • Quantum Communications
  • Quantum Software

Resources & support

  • Research facilities
  • Technical expertise
  • Patent strategy
  • Enterprise connections
  • Academic partnerships
  • Quantum lab access

Website: quantumleap.vc

20. AI Ventures Lab

The go-to ecosystem for AI startups impacting the world through cloud-based AI innovation.

Key info

Program details

  • Investment Terms: $400K for 9% equity
  • Program Length: 5 months
  • Batch Size: 12-15 companies
  • Application Deadlines: Quarterly

Track record

  • AI Categories: 15+
  • Global Reach: 32+ countries
  • Industries Served: 124+
  • Diversity Investments: 55+
  • Success Rate: 85%

Focus areas

  • Machine Vision
  • Speech Recognition
  • Machine Learning
  • Expert Systems
  • Natural Language Processing
  • Robotics & Autonomous Vehicles

Resources & support

  • Cloud infrastructure
  • AI model optimization
  • Technical mentorship
  • Dataset access
  • Enterprise partnerships
  • Deployment support

Website: aiventurelabs.com/home

21. Impact Accelerator

The startup accelerator made by top accelerators, global brands and VCs, offering a rigorous and delocalized acceleration experience.

Key info

Program details

  • Investment Terms: Up to €100K equity free
  • Program Length: 5 months
  • Batch Size: 20-25 companies
  • Application Deadlines: Three times per year

Track record

  • Programs Across Regions: 10+
  • Notable Alumni: Multiple successful European startups
  • Corporate Partners: 50+
  • Diversity Investments: 70+
  • Success Rate: 80%

Focus areas

  • Sustainable Mobility
  • Connected Vehicles
  • Robotics & Automation
  • Digital Innovation
  • Smart Cities
  • Clean Technology

Resources & support

  • Intensive mentoring (40+ hours)
  • Global network access
  • Corporate partnerships
  • Funding opportunities
  • Innovation programs
  • International expansion

Website: impact-accelerator.com

Preparing for demo day

Demo Day is crucial for securing follow-on funding. Here's how to maximize your success:

  1. Perfect your pitch

    • Craft a compelling narrative
    • Focus on traction and growth metrics
    • Clearly articulate your competitive advantage
  2. Prepare your materials

    • Create an investor-ready pitch deck
    • Develop a comprehensive data room
    • Prepare detailed financial projections
  3. Practice and refine

    • Rehearse with mentors and peers
    • Record and analyze your presentation
    • Prepare for common investor questions

Track your application progress

Monitor accelerator partner engagement with your application materials:

  1. Get notified when partners review your deck
  2. Track engagement metrics
  3. Follow up strategically
  4. Protect sensitive information

Choosing your SF accelerator in 2025

San Francisco's accelerators and incubators remain the world's premier launchpad for ambitious startups. With acceptance rates as low as 1-2%, thorough preparation is crucial. Choose a program that aligns with your startup's stage and goals, prepare a compelling pitch, and use secure sharing tools to protect your IP during applications.

Remember: The right accelerator can dramatically accelerate your startup's growth - but only if you're ready to make the most of it.

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